Phosphorylation Regulates Assembly of the Caspase-6 Substrate-Binding Groove
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چکیده
منابع مشابه
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Caspases, a family of apoptotic proteases, are increasingly recognized as being extensively phosphorylated, usually leading to inactivation. To date, no structural mechanism for phosphorylation-based caspase inactivation is available, although this information may be key to achieving caspase-specific inhibition. Caspase-6 has recently been implicated in neurodegenerative conditions including Hu...
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ژورنال
عنوان ژورنال: Structure
سال: 2012
ISSN: 0969-2126
DOI: 10.1016/j.str.2012.02.003